Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes.

ABSTRACT: Fractures are among the most common human traumas. Fracture healing represents a unique temporarily definable post-natal process in which to study the complex interactions of multiple molecular events that regulate endochondral skeletal tissue formation. Because of the regenerative nature of fracture healing, it is hypothesized that large numbers of post-natal stem cells are recruited and contribute to formation of the multiple cell lineages that contribute to this process. Bayesian modeling was used to generate the temporal profiles of the transcriptome during fracture healing. The temporal relationships between ontologies that are associated with various biologic, metabolic, and regulatory pathways were identified and related to developmental processes associated with skeletogenesis, vas

SUBMITTER: Bais M 

PROVIDER: S-EPMC2673045 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature