Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.

ABSTRACT:

Background

Cardiac conduction, as assessed by electrocardiographic PR interval and QRS duration, is an important electrophysiological trait and a determinant of arrhythmia risk.

Objective

We sought to identify common genetic determinants of these measures.

Methods

We examined 1604 individuals from the island of Kosrae, Federated States of Micronesia, an isolated founder population. We adjusted for covariates and estimated the heritability of quantitative electrocardiographic QRS duration and PR interval and, secondarily, its subcomponents, P-wave duration and PR segment. Finally, we performed a genome-wide association study (GWAS) in a subset of 1262 individuals genotyped using the Affymetrix GeneChip Human Mapping 500K microarray.

Results

The heritability of P

SUBMITTER: Smith JG 

PROVIDER: S-EPMC2673462 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature