MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel.

ABSTRACT:

Background

The role of the MYC oncogene in the apoptotic pathways is not fully understood. MYC has been reported to protect cells from apoptosis activation but also to sensitize cells to apoptotic stimuli. We have previously demonstrated that the down-regulation of Myc protein activates apoptosis in melanoma cells and increases the susceptibility of cells to various antitumoral treatments. Beyond the well-known role in the G1-->S transition, MYC is also involved in the G2-M cell cycle phases regulation.

Methodology/principal findings

In this study we have investigated how MYC could influence cell survival signalling during G2 and M phases. We used the microtubules damaging agent paclitaxel (PTX), to arrest the cells in the M phase, in a p53 mutated melanoma cell line with mo

SUBMITTER: Gatti G 

PROVIDER: S-EPMC2673584 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature