Photoregulated release of caged anticancer drugs from gold nanoparticles.

ABSTRACT: An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

SUBMITTER: Agasti SS 

PROVIDER: S-EPMC2673701 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature