Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells.

ABSTRACT:

Background

Monocytes and macrophages play essential role in innate immunity. Understanding the underlying mechanism of macrophage differentiation and the identification of regulatory mechanisms will help to find new strategies to prevent their harmful effects in chronic inflammatory diseases and sepsis.

Results

Maturation of blood monocytes into tissue macrophages and subsequent inflammatory response was mimicked in U937 cells of human histocytic lymphoma origin. Whole genome array analysis was employed to evaluate gene expression profile to identify underlying transcriptional networks implicated during the processes of differentiation and inflammation. In addition to already known transcription factors (i.e. MAFB, EGR, IRF, BCL6, NFkB, AP1, Nur77), gene expression analysis

SUBMITTER: Baek YS 

PROVIDER: S-EPMC2674038 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature