Large scale genotyping study for asthma in the Japanese population.

ABSTRACT:

Background

Asthma is a complex phenotype that is influenced by both genetic and environmental factors. Genome-wide linkage and association studies have been performed to identify susceptibility genes for asthma. These studies identified new genes and pathways implicated in this disease, many of which were previously unknown.

Objective

To perform a large-scale genotyping study to identify asthma-susceptibility genes in the Japanese population.

Methods

We performed a large-scale, three-stage association study on 288 atopic asthmatics and 1032 controls, by using multiplex PCR-Invader assay methods at 82,935 single nucleotide polymorphisms (SNPs) (1st stage). SNPs that were strongly associated with asthma were further genotyped in samples from asthmatic families (216 fami

SUBMITTER: Imada Y 

PROVIDER: S-EPMC2674055 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature