Influence of genetic background on the occurrence of chromosomal rearrangements in Saccharomyces cerevisiae.

ABSTRACT:

Background

Chromosomal rearrangements such as duplications and deletions are key factors in evolutionary processes because they promote genomic plasticity. Although the genetic variations in the Saccharomyces cerevisiae species have been well documented, there is little known to date about the impact of the genetic background on the appearance of rearrangements.

Results

Using the same genetic screening, the type of rearrangements and the mutation rates observed in the S288c S. cerevisiae strain were compared to previous findings obtained in the FL100 background. Transposon-associated rearrangements, a major chromosomal rearrangement event selected in FL100, were not detected in S288c. The mechanisms involved in the occurrence of deletions and duplications in the S288c strain

SUBMITTER: Fritsch ES 

PROVIDER: S-EPMC2674068 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature