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SBF transcription factor complex positively regulates UV mutagenesis in Saccharomyces cerevisiae.


ABSTRACT: The collection of gene deletion mutants of Saccharomyces cerevisiae was used to screen for novel genes required for UV-induced mutagenesis. We found the SBF transcription factor (Swi4/Swi6 protein complex) to be required for wild-type levels of UV mutability in forward and reverse mutation assays. Expression of translesion polymerase zeta component Rev7 was identified as a target of SBF-dependent regulation.

SUBMITTER: Gong J 

PROVIDER: S-EPMC2674285 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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SBF transcription factor complex positively regulates UV mutagenesis in Saccharomyces cerevisiae.

Gong Jinjun J   Siede Wolfram W  

Biochemical and biophysical research communications 20090114 4


The collection of gene deletion mutants of Saccharomyces cerevisiae was used to screen for novel genes required for UV-induced mutagenesis. We found the SBF transcription factor (Swi4/Swi6 protein complex) to be required for wild-type levels of UV mutability in forward and reverse mutation assays. Expression of translesion polymerase zeta component Rev7 was identified as a target of SBF-dependent regulation. ...[more]

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