Evolution of alternative and constitutive regions of mammalian 5'UTRs.

ABSTRACT:

Background

Alternative splicing (AS) in protein-coding sequences has emerged as an important mechanism of regulation and diversification of animal gene function. By contrast, the extent and roles of alternative events including AS and alternative transcription initiation (ATI) within the 5'-untranslated regions (5'UTRs) of mammalian genes are not well characterized.

Results

We evaluated the abundance, conservation and evolution of putative regulatory control elements, namely, upstream start codons (uAUGs) and open reading frames (uORFs), in the 5'UTRs of human and mouse genes impacted by alternative events. For genes with alternative 5'UTRs, the fraction of alternative sequences (those present in a subset of the transcripts) is much greater than that in the corresponding cod

SUBMITTER: Resch AM 

PROVIDER: S-EPMC2674463 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature