A systematic classification of Plasmodium falciparum P-loop NTPases: structural and functional correlation.

ABSTRACT:

Background

The P-loop NTPases constitute one of the largest groups of globular protein domains that play highly diverse functional roles in most of the organisms. Even with the availability of nearly 300 different Hidden Markov Models representing the P-loop NTPase superfamily, not many P-loop NTPases are known in Plasmodium falciparum. A number of characteristic attributes of the genome have resulted into the lack of knowledge about this functionally diverse, but important class of proteins.

Method

In the study, protein sequences with characteristic motifs of NTPase domain (Walker A and Walker B) are computationally extracted from the P. falciparum database. A detailed secondary structure analysis, functional classification, phylogenetic and orthology studies of the NTPase

SUBMITTER: Gangwar D 

PROVIDER: S-EPMC2674469 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature