Total synthesis of sporolide B.

ABSTRACT: An ocean of discovery: The first total synthesis of the highly oxygenated, marine-derived, natural product sporolide B has been achieved through a convergent strategy. The key steps involve a ruthenium-catalyzed [2+2+2] cycloaddition to assemble the indene structural motif and a thermally induced Diels-Alder-type reaction to forge the macrocycle (see scheme).

SUBMITTER: Nicolaou KC 

PROVIDER: S-EPMC2674522 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature