Application of Daugulis copper-catalyzed direct arylation to the synthesis of 5-aryl benzotriazepines.

ABSTRACT: A method for the direct arylation of benzotriazepines is reported, employing an aryl iodide as the coupling partner, copper iodide as the catalyst, and lithium tert-butoxide as the base. A variety of electron-rich, electron-poor, and sterically hindered aryl iodides are compatible with the reaction conditions. The arylation reaction can also be performed outside a glovebox in air without a significant decrease in yield. Furthermore, convenient microwave conditions for carrying out this transformation are reported.

SUBMITTER: Yotphan S 

PROVIDER: S-EPMC2674648 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature