PIRSF family classification system for protein functional and evolutionary analysis.

ABSTRACT: The PIRSF protein classification system (http://pir.georgetown.edu/pirsf/) reflects evolutionary relationships of full-length proteins and domains. The primary PIRSF classification unit is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture). PIRSF families are curated systematically based on literature review and integrative sequence and functional analysis, including sequence and structure similarity, domain architecture, functional association, genome context, and phyletic pattern. The results of classification and expert annotation are summarized in PIRSF family reports with graphical viewers for taxonomic distribution, domain architecture, family hierarchy

SUBMITTER: Nikolskaya AN 

PROVIDER: S-EPMC2674652 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature