Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer.

ABSTRACT:

Purpose

Colon tumors with defective DNA mismatch repair (dMMR) have a well-characterized phenotype and accounts for approximately 15% to 20% of sporadic colon cancer as well as those colon cancer patients with Lynch syndrome. Although the presence of dMMR seems to be a favorable prognostic marker, data suggest that these patients do not respond as well to adjuvant chemotherapy.

Experimental design

In this study, we examined the prognostic significance of tumor MMR deficiency and the presence of a specific mutation in BRAF (V600E) in a group of patients (n = 533) who participated in a randomized prospective clinical trial through the North Central Cancer Treatment Group.

Results

Tumors with dMMR were found to be associated with higher tumor grade (P = 0.001), proximal

SUBMITTER: French AJ 

PROVIDER: S-EPMC2674786 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature