Vaccinia virus G8R protein: a structural ortholog of proliferating cell nuclear antigen (PCNA).

ABSTRACT:

Background

Eukaryotic DNA replication involves the synthesis of both a DNA leading and lagging strand, the latter requiring several additional proteins including flap endonuclease (FEN-1) and proliferating cell nuclear antigen (PCNA) in order to remove RNA primers used in the synthesis of Okazaki fragments. Poxviruses are complex viruses (dsDNA genomes) that infect eukaryotes, but surprisingly little is known about the process of DNA replication. Given our previous results that the vaccinia virus (VACV) G5R protein may be structurally similar to a FEN-1-like protein and a recent finding that poxviruses encode a primase function, we undertook a series of in silico analyses to identify whether VACV also encodes a PCNA-like protein.

Results

An InterProScan of all VACV proteins

SUBMITTER: Da Silva M 

PROVIDER: S-EPMC2674943 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature