Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.

ABSTRACT:

Background

Neuregulin1 (NRG1) influences the development of white matter connectivity and is implicated in genetic susceptibility to schizophrenia. The cingulum bundle is a white matter structure implicated in schizophrenia. Its anterior component is especially implicated, as it provides reciprocal connections between brain regions with prominent involvement in the disorder. Abnormalities in the structural integrity of the anterior cingulum in patients with schizophrenia have been reported previously. The present study investigated the potential contribution of NRG1 variation to anterior cingulum abnormalities in participants with schizophrenia.

Methods

We studied 31 men with schizophrenia and 36 healthy men using diffusion tensor imaging to investigate the association betwe

SUBMITTER: Wang F 

PROVIDER: S-EPMC2674970 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature