Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population.

ABSTRACT:

Background

Bipolar disorder is a widespread and severe brain disorder that is strongly affected by genetic factors. The PDZ and LIM domain 5 (PDLIM5) gene encodes a protein as an Enigma homologue LIM domain protein, which has been widely reported as being expressed in various brain regions. The analysis of DNA microarrays in the frontal lobes of patients with bipolar disorder has indicated changes in the expression level of PDLIM5, and subsequent studies have suggested that PDLIM5 might play a role in susceptibility to bipolar disorder. We sought to examine the association between PDLIM5 and bipolar disorder.

Methods

We recruited 502 patients with bipolar disorder and 507 controls from Anhui Province, China. We conducted a case-control study of 4 single-nucleotide polymorphi

SUBMITTER: Zhao T 

PROVIDER: S-EPMC2674973 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature