Construction and clarification of dynamic gene regulatory network of cancer cell cycle via microarray data.

ABSTRACT:

Background

Cell cycle is an important clue to unravel the mechanism of cancer cells. Recently, expression profiles of cDNA microarray data of Cancer cell cycle are available for the information of dynamic interactions among Cancer cell cycle related genes. Therefore, it is more appealing to construct a dynamic model for gene regulatory network of Cancer cell cycle to gain more insight into the infrastructure of gene regulatory mechanism of cancer cell via microarray data.

Results

Based on the gene regulatory dynamic model and microarray data, we construct the whole dynamic gene regulatory network of Cancer cell cycle. In this study, we trace back upstream regulatory genes of a target gene to infer the regulatory pathways of the gene network by maximum likelihood estimation m

SUBMITTER: Li CW 

PROVIDER: S-EPMC2675491 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature