Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway.

ABSTRACT:

Rationale

Although there have been numerous studies on the development of allergen-induced inflammation, the mechanisms leading to resolution of inflammation remain poorly understood. This represents an important consideration because failure to resolve allergen driven inflammation potentially leads to irreversible airway remodeling, characteristic of chronic asthma.

Objectives

We investigated the resolution of allergic inflammation and identified the factors responsible.

Methods

BALB/c and C57BL/6 mice were sensitized to ovalbumin and challenged through the airways to induce allergic inflammation. Mice were analyzed at 24 hours and 7 days after the final challenge.

Measurements and main results

Airway hyperreactivity (AHR) and increased mucus production were p

SUBMITTER: Kearley J 

PROVIDER: S-EPMC2675564 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature