Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease.

ABSTRACT:

Rationale

Portopulmonary hypertension (PPHTN) occurs in 6% of liver transplant candidates. The pathogenesis of this complication of portal hypertension is poorly understood.

Objectives

To identify genetic risk factors for PPHTN in patients with advanced liver disease.

Methods

We performed a multicenter case-control study of patients with portal hypertension. Cases had a mean pulmonary artery pressure >25 mm Hg, pulmonary vascular resistance >240 dynes.s(-1).cm(-5), and pulmonary capillary wedge pressure < or =15 mm Hg. Controls had a right ventricular systolic pressure < 40 mm Hg (if estimated) and normal right-sided cardiac morphology by transthoracic echocardiography. We genotyped 1,079 common single nucleotide polymorphisms (SNPs) in 93 candidate genes in each pati

SUBMITTER: Roberts KE 

PROVIDER: S-EPMC2675568 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature