Interactions that drive Sec-dependent bacterial protein transport.

ABSTRACT: Understanding the transport of hydrophilic proteins across biological membranes continues to be an important undertaking. The general secretory (Sec) pathway in Escherichia coli transports the majority of E. coli proteins from their point of synthesis in the cytoplasm to their sites of final localization, associating sequentially with a number of protein components of the transport machinery. The targeting signals for these substrates must be discriminated from those of proteins transported via other pathways. While targeting signals for each route have common overall characteristics, individual signal peptides vary greatly in their amino acid sequences. How do these diverse signals interact specifically with the proteins that comprise the appropriate transport machinery and, at the same t

SUBMITTER: Rusch SL 

PROVIDER: S-EPMC2675607 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature