Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt.

ABSTRACT: During development, elaborate patterns of cell differentiation and movement must occur in the correct locations and at the proper times. Developmental timing has been studied less than spatial pattern formation, and the mechanisms integrating the two are poorly understood. Border-cell migration in the Drosophila ovary occurs specifically at stage 9. Timing of the migration is regulated by the steroid hormone ecdysone, whereas spatial patterning of the migratory population requires localized activity of the JAK-STAT pathway. Ecdysone signalling is patterned spatially as well as temporally, although the mechanisms are not well understood. In stage 9 egg chambers, ecdysone signalling is highest in anterior follicle cells including the border cells. We identify the gene abrupt as a repressor o

SUBMITTER: Jang AC 

PROVIDER: S-EPMC2675665 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature