Identification and characterization of renal cell carcinoma gene markers.

ABSTRACT: Microarray gene expression profiling has been used to distinguish histological subtypes of renal cell carcinoma (RCC), and consequently to identify specific tumor markers. The analytical procedures currently in use find sets of genes whose average differential expression across the two categories differ significantly. In general each of the markers thus identified does not distinguish tumor from normal with 100% accuracy, although the group as a whole might be able to do so. For the purpose of developing a widely used economically viable diagnostic signature, however, large groups of genes are not likely to be useful. Here we use two different methods, one a support vector machine variant, and the other an exhaustive search, to reanalyze data previously generated in our Lab (Lenburg et al.

SUBMITTER: Dalgin GS 

PROVIDER: S-EPMC2675843 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature