Genetics of atrial fibrillation.

ABSTRACT: Recent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.

SUBMITTER: Lubitz SA 

PROVIDER: S-EPMC2675914 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature