Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis.

ABSTRACT: Arsenicals are both environmental carcinogens as well as therapeutic agents for the treatment of trypanosomiasis and more recently cancer. Arsenic trioxide (ATO) has been successfully used for the treatment of acute promyelocytic leukemia (APL) and has activity in multiple myeloma (MM). While signaling events associated with carcinogenesis have been well studied, it still remains to be determined which of these events are involved in anti-cancer signaling. To better define this response, gene expression profiling following ATO treatment of four MM cell lines was performed. The pattern was consistent with a strong antioxidative response, particularly of genes activated by Nrf2. While Nrf2 is expressed constitutively at the mRNA level, the protein is not detected in untreated cells. Consiste

SUBMITTER: Morales AA 

PROVIDER: S-EPMC2676019 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature