Association of genetic variants with chronic kidney disease in Japanese individuals.

ABSTRACT:

Background and objectives

Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to chronic kidney disease (CKD), the genes that underlie genetic susceptibility to this condition have remained uncharacterized. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals.

Design, setting, participants, & measurements

The study population comprised 5217 Japanese individuals (2955 men, 2262 women), including 778 subjects (480 men, 298 women) with CKD [estimated GFR (eGFR), <50 ml min(-1) 1.73 m(-2)] and 4439 controls (2475 men, 1964 women; eGFR, > or =60 ml min(-1) 1.73 m(-2)). The genotypes for 40 polymorphisms of 32 candidate genes were determin

SUBMITTER: Yoshida T 

PROVIDER: S-EPMC2676181 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature