DbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation.

ABSTRACT:

Background

MicroRNAs (miRNAs) regulate several biological processes through post-transcriptional gene silencing. The efficiency of binding of miRNAs to target transcripts depends on the sequence as well as intramolecular structure of the transcript. Single Nucleotide Polymorphisms (SNPs) can contribute to alterations in the structure of regions flanking them, thereby influencing the accessibility for miRNA binding.

Description

The entire human genome was analyzed for SNPs in and around predicted miRNA target sites. Polymorphisms within 200 nucleotides that could alter the intramolecular structure at the target site, thereby altering regulation were annotated. Collated information was ported in a MySQL database with a user-friendly interface accessible through the URL: (http:

SUBMITTER: Hariharan M 

PROVIDER: S-EPMC2676258 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature