Analysis of neonatal clinical trials with twin births.

ABSTRACT:

Background

In neonatal trials of pre-term or low-birth-weight infants, twins may represent 10-20% of the study sample. Mixed-effects models and generalized estimating equations are common approaches for handling correlated continuous or binary data. However, the operating characteristics of these methods for mixes of correlated and independent data are not well established.

Methods

Simulation studies were conducted to compare mixed-effects models and generalized estimating equations to linear regression for continuous outcomes. Similarly, mixed-effects models and generalized estimating equations were compared to ordinary logistic regression for binary outcomes. The parameter of interest is the treatment effect in two-armed clinical trials. Data from the National Institute of

SUBMITTER: Shaffer ML 

PROVIDER: S-EPMC2676314 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature