Enhanced monocyte response and decreased central memory T cells in children with invasive Staphylococcus aureus infections.

ABSTRACT: Staphylococcus aureus has emerged as a significant pathogen causing severe invasive disease in otherwise healthy people. Despite considerable advances in understanding the epidemiology, resistance mechanisms, and virulence factors produced by the bacteria, there is limited knowledge of the in vivo host immune response to acute, invasive S. aureus infections. Herein, we report that peripheral blood mononuclear cells from patients with severe S. aureus infections demonstrate a distinctive and robust gene expression profile which is validated in a distinct group of patients and on a different microarray platform. Application of a systems-wide modular analysis framework reveals significant over-expression of innate immunity genes and under-expression of genes related to adaptive immunity. Simu

SUBMITTER: Ardura MI 

PROVIDER: S-EPMC2676512 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature