Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study.

ABSTRACT:

Background and purpose

Carotid intima-media thickness (IMT) is a surrogate marker of subclinical atherosclerosis and a strong predictor of stroke and myocardial infarction. The object of this study was to determine the association between carotid IMT and 702 single nucleotide polymorphisms in 145 genes.

Methods

B-mode carotid ultrasound was performed among 408 Hispanics from the Northern Manhattan Study. The common carotid artery IMT and bifurcation IMT were phenotypes of interest. Genetic effects were evaluated by the multivariate regression model adjusting for traditional vascular risk factors. For each individual, we calculated a gene risk score (GRS) defined as the total number of the significant single nucleotide polymorphisms in different genes. Subjects were then divi

SUBMITTER: Liao YC 

PROVIDER: S-EPMC2676928 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature