Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study.

ABSTRACT:

Objective

Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up.

Methods

Data were from a population-based cohort study comprising 1,789 older Mexican Americans. All participants had cognitive and clinical evaluations performed every 12 to 15 months. Participants who fell below specified cutpoints on cognitive tests were then evaluated clinically. Dementia diagnoses were finalized by an adjudication team. A total of 1,674 participants free of dementia/CIND at baseline were included in these analyses. Statin use was verified at each participant's home by medicine cabinet inspe

SUBMITTER: Cramer C 

PROVIDER: S-EPMC2676946 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature