Augmented neural activity during executive control processing following diffuse axonal injury.

ABSTRACT:

Background

Deficits in working memory are commonly observed after traumatic brain injury (TBI), with executive control processes preferentially impacted relative to storage and rehearsal. Previous activation functional neuroimaging investigations of working memory in patients with TBI have reported altered functional recruitment, but methodologic issues including sample heterogeneity (e.g., variability in injury mechanism, severity, neuropathology or chronicity), underspecified definitions of "working memory," and behavioral differences between TBI and control groups have hindered interpretation of these changes.

Methods

Executive control processing in working memory was explicitly engaged during fMRI in a sample of carefully selected chronic-stage, moderate-to-severe TBI pa

SUBMITTER: Turner GR 

PROVIDER: S-EPMC2676953 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature