Familiality in brain tumors.

ABSTRACT:

Background

Familiality in brain tumors is not definitively substantiated.

Methods

We used the Utah Population Data Base (UPDB), a genealogy representing the Utah pioneers and their descendants, record-linked to statewide cancer records, to describe the familial nature of primary brain cancer. We examined the familial clustering of primary brain tumors, including subgroups defined by histologic type and age at diagnosis. The UPDB includes 1,401 primary brain tumor cases defined as astrocytoma or glioblastoma, all with at least three generations of genealogy data. We tested the hypothesis of excess relatedness of brain tumor cases using the Genealogical Index of Familiality method. We estimated relative risks for brain tumors in relatives using rates of brain tumors estimated

SUBMITTER: Blumenthal DT 

PROVIDER: S-EPMC2676956 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature