The HAT Score: a simple grading scale for predicting hemorrhage after thrombolysis.

ABSTRACT:

Objective

To develop a grading scale to predict the risk of intracerebral hemorrhage (ICH) and prognosis after treatment with IV tissue-plasminogen activator (t-PA) in patients with ischemic stroke.

Methods

We constructed a five-point scale based on NIH Stroke Scale score, extent of hypodensity on CT scan, serum glucose at baseline, and history of diabetes to predict the risk of hemorrhage after thrombolysis (HAT score). We evaluated the predictive ability of this scale, using c-statistics, in two independent cohorts: the t-PA treated group in the National Institute of Neurological Disorders and Stroke study, and consecutive patients treated with IV t-PA at our institution.

Results

The percentage of patients who developed any ICH after t-PA increased with higher score

SUBMITTER: Lou M 

PROVIDER: S-EPMC2676961 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature