Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease.

ABSTRACT:

Background

Despite convenience, accessibility, and strong correlation to severity of Alzheimer disease (AD) pathology, medial temporal lobe atrophy (MTA) has not been used as a criterion in the diagnosis of prodromal and probable AD.

Methods

Using a newly validated visual rating system, mean MTA scores of three bilateral medial temporal lobe structures were compared for subjects with no cognitive impairment (NCI) (n = 117), nonamnestic mild cognitive impairment (MCI) (n = 46), amnestic MCI (n = 45), and probable AD (n = 53). Correlations between MTA scores and neuropsychological test scores at baseline, and predictors of change in diagnosis at 1-year follow-up were evaluated.

Results

With NCI as the reference group, a mean MTA cut score of 1.33 yielded an optimal sens

SUBMITTER: Duara R 

PROVIDER: S-EPMC2676975 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature