Serum cystatin C and the risk of Alzheimer disease in elderly men.

ABSTRACT:

Background

Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD).

Methods

Serum cystatin C levels were analyzed at two examinations of the Uppsala Longitudinal Study of Adult Men, a longitudinal, community-based study of elderly men (age 70 years, n = 1,153 and age 77 years, n = 761, a subset of the age 70 examination). Cox regressions were used to examine associations between serum cystatin C and incident AD. AD cases were identified by cognitive screening and comprehensive medical chart review in all subjects.

Results

On follow-up (median 11.3 years), 82 subjects developed AD. At age 70 years, lower cystatin C was associated with higher risk of AD independently of age, APOE4 geno

SUBMITTER: Sundelof J 

PROVIDER: S-EPMC2676985 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature