Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.

ABSTRACT:

Background

A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis.

Objective

The objective was to assess whether established genetic variants, mainly from genomewide association studies, modify dietary patterns in predicting diabetes risk.

Design

We determined 10 polymorphisms in a prospective, nested, case-control study of 1196 diabetic and 1337 nondiabetic men. A genetic risk score (GRS) was generated by using an allele counting method. Baseline dietary intakes were collected by using a semiquantitative food-frequency questionnaire. We used factor analysis to derive Western and "Prudent" dietary patterns from 40 food groups.

Re

SUBMITTER: Qi L 

PROVIDER: S-EPMC2676999 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature