Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone.

ABSTRACT:

Background

Age-related reductions in serum dehydroepiandrosterone (DHEA) concentrations may be involved in bone mineral density (BMD) losses.

Objective

The objective was to determine whether DHEA supplementation in older adults improves BMD when co-administered with vitamin D and calcium.

Design

In year 1, a randomized trial was conducted in which men (n = 55) and women (n = 58) aged 65-75 y took 50 mg/d oral DHEA supplements or placebo. In year 2, all participants took open-label DHEA (50 mg/d). During both years, all participants received vitamin D (16 microg/d) and calcium (700 mg/d) supplements. BMD was measured by using dual-energy X-ray absorptiometry. Concentrations of hormones and bone turnover markers were measured in serum.

Results

In men, no differen

SUBMITTER: Weiss EP 

PROVIDER: S-EPMC2677000 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature