Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress.

ABSTRACT:

Background

Oxidative stress (OS) is an important factor in brain aging and neurodegenerative diseases. Certain neurons in different brain regions exhibit selective vulnerability to OS. Currently little is known about the underlying mechanisms of this selective neuronal vulnerability. The purpose of this study was to identify endogenous factors that predispose vulnerable neurons to OS by employing genomic and biochemical approaches.

Results

In this report, using in vitro neuronal cultures, ex vivo organotypic brain slice cultures and acute brain slice preparations, we established that cerebellar granule (CbG) and hippocampal CA1 neurons were significantly more sensitive to OS (induced by paraquat) than cerebral cortical and hippocampal CA3 neurons. To probe for intrinsic diff

SUBMITTER: Wang X 

PROVIDER: S-EPMC2677396 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature