The cortical signature of prodromal AD: regional thinning predicts mild AD dementia.

ABSTRACT:

Objective

We previously used exploratory analyses across the entire cortex to determine that mild Alzheimer disease (AD) is reliably associated with a cortical signature of thinning in specific limbic and association regions. Here we investigated whether the cortical signature of AD-related thinning is present in individuals with questionable AD dementia (QAD) and whether a greater degree of regional cortical thinning predicts mild AD dementia.

Methods

Participants included 49 older adults with mild impairment consistent with mild cognitive impairment (Clinical Dementia Rating [CDR] = 0.5) at the time of structural MRI scanning. Cortical thickness was measured in nine regions of interest (ROIs) identified previously from a comparison of patients with mild AD and controls.

SUBMITTER: Bakkour A 

PROVIDER: S-EPMC2677470 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature