PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids.

ABSTRACT:

Background

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection that develops in immunosuppressed patients with HIV infection. Paradoxically, some of these patients may develop PML during combined antiretroviral therapy in the setting of immune reconstitution. We describe the types of PML in relation to immune reconstitution inflammatory syndrome (IRIS) and the effects of steroid use in these patients.

Methods

We performed a retrospective review of the literature (1998 to 2007) and of all HIV-infected patients diagnosed with PML-IRIS at Johns Hopkins Hospital (2004 to 2007). We recorded information on clinical features, microbiologic and virological analysis, neuroimaging, pathology, treatment, and outcome.

Results

Of 54 patients with PML-IRI

SUBMITTER: Tan K 

PROVIDER: S-EPMC2677476 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature