Adverse antiepileptic drug effects: toward a clinically and neurobiologically relevant taxonomy.

ABSTRACT:

Background

Adverse effects (AEs) of antiepileptic drugs (AEDs) are a major impediment to optimal dosing for seizure control. Better understanding of clinical properties of AEs is a prerequisite for systematic research of their neurobiological underpinnings. This study aimed to define specific patterns of AE occurrence and determine their clinical relevance based on their association with subjective health status.

Methods

Two hundred subjects with epilepsy completed validated self-report health assessments, including the Adverse Event Profile (AEP) and Quality of Life in Epilepsy Inventory (QOLIE)-89. Factor analysis was performed on the 19 AEP items to identify distinct classes of AEs. Correlations between AE class scores and QOLIE-89 scores were evaluated. Multivariate anal

SUBMITTER: Perucca P 

PROVIDER: S-EPMC2677485 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature