Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study.

ABSTRACT:

Objectives

To determine whether menopausal hormone therapy (HT) affects regional brain volumes, including hippocampal and frontal regions.

Methods

Brain MRI scans were obtained in a subset of 1,403 women aged 71-89 years who participated in the Women's Health Initiative Memory Study (WHIMS). WHIMS was an ancillary study to the Women's Health Initiative, which consisted of two randomized, placebo-controlled trials: 0.625 mg conjugated equine estrogens (CEE) with or without 2.5 mg medroxyprogesterone acetate (MPA) in one daily tablet. Scans were performed, on average, 3.0 years post-trial for the CEE + MPA trial and 1.4 years post-trial for the CEE-Alone trial; average on-trial follow-up intervals were 4.0 years for CEE + MPA and 5.6 years for CEE-Alone. Total brain, ventricul

SUBMITTER: Resnick SM 

PROVIDER: S-EPMC2677493 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature