Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline.

ABSTRACT:

Background

In some prospective studies, associations of serum vitamin B(12) and homocysteine concentrations with cognitive decline have been reported but few have examined the role of methylmalonic acid, a more specific marker of vitamin B(12) deficiency than homocysteine.

Objective

The aim of the study was to determine whether serum concentrations of vitamin B(12) or selected metabolites are related to cognitive decline.

Methods

A total of 516 subjects were selected in a stratified random sampling design from among Chicago Health and Aging Project participants for clinical evaluation. We used linear mixed models to examine the association of blood markers of vitamin B(12) status to change in cognitive scores over 6 years. Cognitive function was assessed every 3 years

SUBMITTER: Tangney CC 

PROVIDER: S-EPMC2677500 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature