Treatment of CNS sarcoidosis with infliximab and mycophenolate mofetil.

ABSTRACT:

Objective

To describe the effects of the anti-tumor necrosis factor neutralizing antibody, infliximab, and the antiproliferative immunosuppressant, mycophenolate mofetil, in refractory neurosarcoidosis.

Methods

We treated patients with biopsy-proven sarcoidosis and CNS involvement, who had failed treatment with steroids, with infliximab (5 mg/kg on weeks 0, 2, and 6, and then every 6-8 weeks thereafter). Six out of seven patients were co-treated with mycophenolate mofetil (1,000 mg PO BID). Patients underwent a review of symptoms and complete neurologic examination every 3 months and MRI scanning before and after 3-4 infusions of infliximab.

Results

All patients reported significant symptomatic improvement by the fourth infusion of infliximab, including relief of head

SUBMITTER: Moravan M 

PROVIDER: S-EPMC2677503 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature