Executive dysfunction in frontotemporal dementia and corticobasal syndrome.

ABSTRACT:

Objective

To determine the pattern of executive dysfunction in frontotemporal dementia (FTD) and corticobasal syndrome (CBS) and to determine the brain areas associated with executive dysfunction in these illnesses.

Method

We administered the Delis-Kaplan Executive Function System (D-KEFS), a collection of standardized executive function tests, to 51 patients with behavioral-variant FTD and 50 patients with CBS. We also performed a discriminant analysis on the D-KEFS to determine which executive function tests best distinguished the clinical diagnoses of FTD and CBS. Finally, we used voxel-based morphometry (VBM) to determine regional gray matter volume loss associated with executive dysfunction.

Results

Patients with FTD and patients with CBS showed executive dysfunc

SUBMITTER: Huey ED 

PROVIDER: S-EPMC2677529 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature