Ontology highlight
ABSTRACT:
SUBMITTER: Dickson KA
PROVIDER: S-EPMC2677630 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Biochemistry 20090501 18
Human angiogenin (ANG) is a homologue of bovine pancreatic ribonuclease (RNase A) that induces neovascularization. ANG is the only human angiogenic factor that possesses ribonucleolytic activity. To stimulate blood vessel growth, ANG must be transported to the nucleus and must retain its catalytic activity. Like other mammalian homologues of RNase A, ANG forms a femtomolar complex with the cytosolic ribonuclease inhibitor protein (RI). To determine whether RI affects ANG-induced angiogenesis, we ...[more]