Identification of candidate genes for congenital splay leg in piglets by alternative analysis of DNA microarray data.

ABSTRACT: The congenital splay leg syndrome in piglets is characterized by a temporarily impaired functionality of the hind leg muscles immediately after birth. Etiology and pathogenetic mechanisms for the disease are still not well understood. We compared genome wide gene expression of three hind leg muscles (M. adductores, M. gracilis and M. sartorius) between affected piglets and their healthy littermates with the GeneChip Porcine Genome Array (Affymetrix) in order to identify candidate genes for the disease. Data analysis with standard algorithms revealed no significant differences between both groups. By application of an alternative approach, we identified 63 transcripts with differences in two muscles and 5 genes differing between the groups in three muscles. The expression of six selected ge

SUBMITTER: Maak S 

PROVIDER: S-EPMC2677734 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature