The relation between inflammation and neurodegeneration in multiple sclerosis brains.

ABSTRACT: Some recent studies suggest that in progressive multiple sclerosis, neurodegeneration may occur independently from inflammation. The aim of our study was to analyse the interdependence of inflammation, neurodegeneration and disease progression in various multiple sclerosis stages in relation to lesional activity and clinical course, with a particular focus on progressive multiple sclerosis. The study is based on detailed quantification of different inflammatory cells in relation to axonal injury in 67 multiple sclerosis autopsies from different disease stages and 28 controls without neurological disease or brain lesions. We found that pronounced inflammation in the brain is not only present in acute and relapsing multiple sclerosis but also in the secondary and primary progressive disease.

SUBMITTER: Frischer JM 

PROVIDER: S-EPMC2677799 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature