High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance.

ABSTRACT: Childhood cancer survivors often experience complications related to cancer and its treatment that may adversely affect quality of life and increase the risk of premature death. The purpose of this manuscript is to review how data derived from Childhood Cancer Survivor Study (CCSS) investigations have facilitated identification of childhood cancer survivor populations at high risk for specific organ toxicity and secondary carcinogenesis and how this has informed clinical screening practices. Articles previously published that used the resource of the CCSS to identify risk factors for specific organ toxicity and subsequent cancers were reviewed and results summarized. CCSS investigations have characterized specific groups to be at highest risk of morbidity related to endocrine and reproduct

SUBMITTER: Hudson MM 

PROVIDER: S-EPMC2677926 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature